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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of age-related macular degeneration (AMD)
ncRNA name hsa-miR-29
ncRNA Category miRNA
Disease name age-related macular degeneration (AMD)
Species Homo sapiens
Tissues/Cell_line primary human RPE cells; human RPE cell line ARPE-19; human embryonic kidney cell line HEK293
Methods transfection, luciferase reporter assay, Western blot, qPCR, autophagy flux assay, immunofluorescence
Expression pattern down-regulated
Functional description miR-29 enhances autophagy which aids in removal of protein aggregates.
PubMed ID 30513336
Year 2019
Title MicroRNA-29 enhances autophagy and cleanses exogenous mutant αB-crystallin in retinal pigment epithelial cells.
Drug-related ncRNA NO

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